Search on: COMPLEMENT COMPONENT 5 
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Descriptor English:   Complement C5 
Descriptor Spanish:   Complemento C5 
Descriptor Portuguese:   Complemento C5 
Synonyms English:   C5 Complement
Complement 5
Complement C5, Precursor
Complement Component 5
Precursor C5
Pro-C5
Pro-complement 5
C5, Complement
C5, Precursor
C5, Precursor Complement
Complement, C5
Component 5, Complement
Precursor Complement C5
Pro C5
Pro complement 5  
Tree Number:   D12.776.124.486.274.450
Definition English:   C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX. 
Pharmacological Action:   Immunologic Factors
 
History Note English:   2006 (1975) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   22137 
Unique Identifier:   D003182 

Occurrence in VHL: 		 

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